STABLE AQUEOUS PHARMACEUTICAL COMPOSITION COMPRISING TEZOSENTAN

STABLE AQUEOUS PHARMACEUTICAL COMPOSITION COMPRISING TEZOSENTAN

Difficulties in preparing a stable pharmaceutical composition containing 5- Isopropyl-pyridine-2- sulfonic acid 6-(2-hydroxy-ethoxy)-5(2-methoxy- phenoxy)2-(2-1H-tetrazol-5-y l- pyridin-4yl)- pyrimidin-4-ylamide in form of the water soluble disodium salt, a buffer and preferably a metal complex form...

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1. Verfasser: LOELIGER, PETER
Format: Patent
Sprache:eng ; fre
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator LOELIGER, PETER
description Difficulties in preparing a stable pharmaceutical composition containing 5- Isopropyl-pyridine-2- sulfonic acid 6-(2-hydroxy-ethoxy)-5(2-methoxy- phenoxy)2-(2-1H-tetrazol-5-y l- pyridin-4yl)- pyrimidin-4-ylamide in form of the water soluble disodium salt, a buffer and preferably a metal complex forming agent, have been encountered. It was unexpectedly found that these difficulties can be overcome by adjusting the pH of the solution with an aci d to over and above 8,2, preferably to 9,0, but not higher than 10.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title STABLE AQUEOUS PHARMACEUTICAL COMPOSITION COMPRISING TEZOSENTAN
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