STABLE AQUEOUS PHARMACEUTICAL COMPOSITION COMPRISING TEZOSENTAN

STABLE AQUEOUS PHARMACEUTICAL COMPOSITION COMPRISING TEZOSENTAN

Difficulties in preparing a stable pharmaceutical composition containing 5- Isopropyl-pyridine-2- sulfonic acid 6-(2-hydroxy-ethoxy)-5(2-methoxy- phenoxy)2-(2-1H-tetrazol-5-y l- pyridin-4yl)- pyrimidin-4-ylamide in form of the water soluble disodium salt, a buffer and preferably a metal complex form...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
1. Verfasser: LOELIGER, PETER
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Difficulties in preparing a stable pharmaceutical composition containing 5- Isopropyl-pyridine-2- sulfonic acid 6-(2-hydroxy-ethoxy)-5(2-methoxy- phenoxy)2-(2-1H-tetrazol-5-y l- pyridin-4yl)- pyrimidin-4-ylamide in form of the water soluble disodium salt, a buffer and preferably a metal complex forming agent, have been encountered. It was unexpectedly found that these difficulties can be overcome by adjusting the pH of the solution with an aci d to over and above 8,2, preferably to 9,0, but not higher than 10.