PLEUROMUTILIN DERIVATIVES AS ANTIMICROBIALS

Derivatives of pleuromutilin of formula (IA) or (IB) in which the glycolic ester moiety at position (14) is replaced by R2(CH2)m X(CH2)n CH2COO are of use in antimicrobial therapy. In which: each of n and m is independently 0, 1 or 2; X is selected from -O-, -S-, S(O)-, -SO2-, -CO.O-, -NH-, -CONH-,...

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Bibliographische Detailangaben
Hauptverfasser:	DABBS, STEVEN, SANDERSON, FRANCIS DOMINIC, FRYDRYCH, COLIN HENRY, HUNT, ERIC, WOODNUTT, GARY, BERRY, VALERIE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Derivatives of pleuromutilin of formula (IA) or (IB) in which the glycolic ester moiety at position (14) is replaced by R2(CH2)m X(CH2)n CH2COO are of use in antimicrobial therapy. In which: each of n and m is independently 0, 1 or 2; X is selected from -O-, -S-, S(O)-, -SO2-, -CO.O-, -NH-, -CONH-, NHCONH- and a bond; R1 is vinyl or ethyl; R2 is a non-aromatic a monocyclic or bicyclic group containing one or two basic nitrogen atoms and attached through a ring carbon atom; R3 is H or OH; or the moiety R2(CH2)m X(CH2)n CH2COO at position 14 of (IA) or (IB) is replaced by R a R b C=CHCOO in which one of R a and R b is hydrogen and the other is R2 or R a and R b together form R2; or a pharmaceutically acceptabl e salt thereof.