PYRIDYLACRYLAMIDE DERIVATIVES AND NEPHRITIS REMEDIES AND TGF-.BETA. INHIBITORS CONTAINING THE SAME
Compounds represented by general formula (I), and nephritis remedies and TGF.beta. inhibitors containing the same, wherein Ar1 is (substituted) pyridyl; Ar2 is (substituted) phenyl; R1 is H, alkyl or aryl; R2 is H, alkyl, cyano or alkoxycarbonyl; R3 is H or (substituted) alkyl; X is O or S; A and B...
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| creator | HAYAKAWA, HIROYUKI KUMAZAWA, HIROAKI HORIUCHI, FUMIKO HASEGAWA, YOSHIHIRO OBATA, TATSUHIRO HATTORI, TOMOHISA YAMAZAKI, YOUSUKE SHINDOU, SHOUICHIROU |
| description | Compounds represented by general formula (I), and nephritis remedies and TGF.beta. inhibitors containing the same, wherein Ar1 is (substituted) pyridyl; Ar2 is (substituted) phenyl; R1 is H, alkyl or aryl; R2 is H, alkyl, cyano or alkoxycarbonyl; R3 is H or (substituted) alkyl; X is O or S; A and B are each H, OH, alkoxy or alkylthio, or alternatively they together form oxo, thioxo, =N-Y (wherein Y is dialkylamino, OH, aralkyloxy or alkoxy) or -Z1-M-Z2- (wherein Z1 and Z2 are each O, S or optionally alkyl-substituted imino; and M is alkylene or phenylene), or B may be 1-alkylimidazol-2-yl with A being OH; and n is an integer of 1 to 3. |
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INHIBITORS CONTAINING THE SAME</title><source>esp@cenet</source><creator>HAYAKAWA, HIROYUKI ; KUMAZAWA, HIROAKI ; HORIUCHI, FUMIKO ; HASEGAWA, YOSHIHIRO ; OBATA, TATSUHIRO ; HATTORI, TOMOHISA ; YAMAZAKI, YOUSUKE ; SHINDOU, SHOUICHIROU</creator><creatorcontrib>HAYAKAWA, HIROYUKI ; KUMAZAWA, HIROAKI ; HORIUCHI, FUMIKO ; HASEGAWA, YOSHIHIRO ; OBATA, TATSUHIRO ; HATTORI, TOMOHISA ; YAMAZAKI, YOUSUKE ; SHINDOU, SHOUICHIROU</creatorcontrib><description>Compounds represented by general formula (I), and nephritis remedies and TGF.beta. inhibitors containing the same, wherein Ar1 is (substituted) pyridyl; Ar2 is (substituted) phenyl; R1 is H, alkyl or aryl; R2 is H, alkyl, cyano or alkoxycarbonyl; R3 is H or (substituted) alkyl; X is O or S; A and B are each H, OH, alkoxy or alkylthio, or alternatively they together form oxo, thioxo, =N-Y (wherein Y is dialkylamino, OH, aralkyloxy or alkoxy) or -Z1-M-Z2- (wherein Z1 and Z2 are each O, S or optionally alkyl-substituted imino; and M is alkylene or phenylene), or B may be 1-alkylimidazol-2-yl with A being OH; and n is an integer of 1 to 3.</description><edition>7</edition><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990204&DB=EPODOC&CC=CA&NR=2298480A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990204&DB=EPODOC&CC=CA&NR=2298480A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HAYAKAWA, HIROYUKI</creatorcontrib><creatorcontrib>KUMAZAWA, HIROAKI</creatorcontrib><creatorcontrib>HORIUCHI, FUMIKO</creatorcontrib><creatorcontrib>HASEGAWA, YOSHIHIRO</creatorcontrib><creatorcontrib>OBATA, TATSUHIRO</creatorcontrib><creatorcontrib>HATTORI, TOMOHISA</creatorcontrib><creatorcontrib>YAMAZAKI, YOUSUKE</creatorcontrib><creatorcontrib>SHINDOU, SHOUICHIROU</creatorcontrib><title>PYRIDYLACRYLAMIDE DERIVATIVES AND NEPHRITIS REMEDIES AND TGF-.BETA. INHIBITORS CONTAINING THE SAME</title><description>Compounds represented by general formula (I), and nephritis remedies and TGF.beta. inhibitors containing the same, wherein Ar1 is (substituted) pyridyl; Ar2 is (substituted) phenyl; R1 is H, alkyl or aryl; R2 is H, alkyl, cyano or alkoxycarbonyl; R3 is H or (substituted) alkyl; X is O or S; A and B are each H, OH, alkoxy or alkylthio, or alternatively they together form oxo, thioxo, =N-Y (wherein Y is dialkylamino, OH, aralkyloxy or alkoxy) or -Z1-M-Z2- (wherein Z1 and Z2 are each O, S or optionally alkyl-substituted imino; and M is alkylene or phenylene), or B may be 1-alkylimidazol-2-yl with A being OH; and n is an integer of 1 to 3.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1999</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNisEKgkAQQL10iOof5geUsg56HHdHd6BdZXcQPInFdooS7P-pgx_Q5T14vG1y6wbPerii8j9Y1gSaPPco3FMAdBocdcazcABPljSvWZo6zSoSzICd4Yql9QFU6wTZsWtADEFAS_tk85ieSzys3iVQkyiTxvk9xmWe7vEVP6PCPC-LS3HE0_mP5QuUvjN7</recordid><startdate>19990204</startdate><enddate>19990204</enddate><creator>HAYAKAWA, HIROYUKI</creator><creator>KUMAZAWA, HIROAKI</creator><creator>HORIUCHI, FUMIKO</creator><creator>HASEGAWA, YOSHIHIRO</creator><creator>OBATA, TATSUHIRO</creator><creator>HATTORI, TOMOHISA</creator><creator>YAMAZAKI, YOUSUKE</creator><creator>SHINDOU, SHOUICHIROU</creator><scope>EVB</scope></search><sort><creationdate>19990204</creationdate><title>PYRIDYLACRYLAMIDE DERIVATIVES AND NEPHRITIS REMEDIES AND TGF-.BETA. 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INHIBITORS CONTAINING THE SAME</title><date>1999-02-04</date><risdate>1999</risdate><abstract>Compounds represented by general formula (I), and nephritis remedies and TGF.beta. inhibitors containing the same, wherein Ar1 is (substituted) pyridyl; Ar2 is (substituted) phenyl; R1 is H, alkyl or aryl; R2 is H, alkyl, cyano or alkoxycarbonyl; R3 is H or (substituted) alkyl; X is O or S; A and B are each H, OH, alkoxy or alkylthio, or alternatively they together form oxo, thioxo, =N-Y (wherein Y is dialkylamino, OH, aralkyloxy or alkoxy) or -Z1-M-Z2- (wherein Z1 and Z2 are each O, S or optionally alkyl-substituted imino; and M is alkylene or phenylene), or B may be 1-alkylimidazol-2-yl with A being OH; and n is an integer of 1 to 3.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | PYRIDYLACRYLAMIDE DERIVATIVES AND NEPHRITIS REMEDIES AND TGF-.BETA. INHIBITORS CONTAINING THE SAME |
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