PYRIDYLACRYLAMIDE DERIVATIVES AND NEPHRITIS REMEDIES AND TGF-.BETA. INHIBITORS CONTAINING THE SAME

PYRIDYLACRYLAMIDE DERIVATIVES AND NEPHRITIS REMEDIES AND TGF-.BETA. INHIBITORS CONTAINING THE SAME

Compounds represented by general formula (I), and nephritis remedies and TGF.beta. inhibitors containing the same, wherein Ar1 is (substituted) pyridyl; Ar2 is (substituted) phenyl; R1 is H, alkyl or aryl; R2 is H, alkyl, cyano or alkoxycarbonyl; R3 is H or (substituted) alkyl; X is O or S; A and B...

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Hauptverfasser: HAYAKAWA, HIROYUKI, KUMAZAWA, HIROAKI, HORIUCHI, FUMIKO, HASEGAWA, YOSHIHIRO, OBATA, TATSUHIRO, HATTORI, TOMOHISA, YAMAZAKI, YOUSUKE, SHINDOU, SHOUICHIROU
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Compounds represented by general formula (I), and nephritis remedies and TGF.beta. inhibitors containing the same, wherein Ar1 is (substituted) pyridyl; Ar2 is (substituted) phenyl; R1 is H, alkyl or aryl; R2 is H, alkyl, cyano or alkoxycarbonyl; R3 is H or (substituted) alkyl; X is O or S; A and B are each H, OH, alkoxy or alkylthio, or alternatively they together form oxo, thioxo, =N-Y (wherein Y is dialkylamino, OH, aralkyloxy or alkoxy) or -Z1-M-Z2- (wherein Z1 and Z2 are each O, S or optionally alkyl-substituted imino; and M is alkylene or phenylene), or B may be 1-alkylimidazol-2-yl with A being OH; and n is an integer of 1 to 3.