ENZYMATIC KINETIC RESOLUTION OF AN INTERMEDIATE USEFUL FOR PREPARING SUBSTITUTED TRICYCLICS
The invention relates to a process for preparing a substituted (6,11-dihydro - 5H-benzo [5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidine compound of formula ((+)-I) wherein: R, R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halo, C1-C6 alkyl, amino, -OCH3, -OCF3 an...
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| creator | LIU, JINCHU MORGAN, WILLIAM BRIAN |
| description | The invention relates to a process for preparing a substituted (6,11-dihydro - 5H-benzo [5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidine compound of formula ((+)-I) wherein: R, R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halo, C1-C6 alkyl, amino, -OCH3, -OCF3 and CF3, and the dotted line represents an option al double bond; comprising: enzymatically catalyzing the acylation of a compound of the formula ((~)-II) wherein the variables are as defined above, and hydrolysing the product to obtain ((+)-I). |
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comprising: enzymatically catalyzing the acylation of a compound of the formula ((~)-II) wherein the variables are as defined above, and hydrolysing the product to obtain ((+)-I).</description><edition>7</edition><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040511&DB=EPODOC&CC=CA&NR=2293708C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040511&DB=EPODOC&CC=CA&NR=2293708C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIU, JINCHU</creatorcontrib><creatorcontrib>MORGAN, WILLIAM BRIAN</creatorcontrib><title>ENZYMATIC KINETIC RESOLUTION OF AN INTERMEDIATE USEFUL FOR PREPARING SUBSTITUTED TRICYCLICS</title><description>The invention relates to a process for preparing a substituted (6,11-dihydro - 5H-benzo [5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidine compound of formula ((+)-I) wherein: R, R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halo, C1-C6 alkyl, amino, -OCH3, -OCF3 and CF3, and the dotted line represents an option al double bond; 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MORGAN, WILLIAM BRIAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2293708C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2004</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LIU, JINCHU</creatorcontrib><creatorcontrib>MORGAN, WILLIAM BRIAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIU, JINCHU</au><au>MORGAN, WILLIAM BRIAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ENZYMATIC KINETIC RESOLUTION OF AN INTERMEDIATE USEFUL FOR PREPARING SUBSTITUTED TRICYCLICS</title><date>2004-05-11</date><risdate>2004</risdate><abstract>The invention relates to a process for preparing a substituted (6,11-dihydro - 5H-benzo [5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidine compound of formula ((+)-I) wherein: R, R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halo, C1-C6 alkyl, amino, -OCH3, -OCF3 and CF3, and the dotted line represents an option al double bond; comprising: enzymatically catalyzing the acylation of a compound of the formula ((~)-II) wherein the variables are as defined above, and hydrolysing the product to obtain ((+)-I).</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY SPIRITS VINEGAR WINE |
| title | ENZYMATIC KINETIC RESOLUTION OF AN INTERMEDIATE USEFUL FOR PREPARING SUBSTITUTED TRICYCLICS |
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