ENZYMATIC KINETIC RESOLUTION OF AN INTERMEDIATE USEFUL FOR PREPARING SUBSTITUTED TRICYCLICS

ENZYMATIC KINETIC RESOLUTION OF AN INTERMEDIATE USEFUL FOR PREPARING SUBSTITUTED TRICYCLICS

The invention relates to a process for preparing a substituted (6,11-dihydro - 5H-benzo [5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidine compound of formula ((+)-I) wherein: R, R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halo, C1-C6 alkyl, amino, -OCH3, -OCF3 an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LIU, JINCHU, MORGAN, WILLIAM BRIAN
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The invention relates to a process for preparing a substituted (6,11-dihydro - 5H-benzo [5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidine compound of formula ((+)-I) wherein: R, R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halo, C1-C6 alkyl, amino, -OCH3, -OCF3 and CF3, and the dotted line represents an option al double bond; comprising: enzymatically catalyzing the acylation of a compound of the formula ((~)-II) wherein the variables are as defined above, and hydrolysing the product to obtain ((+)-I).