ASYMMETRIC HYDROGENATION OF .BETA.-KETO ESTERS

Enantiomerically pure .beta.-hydroxy esters are prepared by a process in which .beta.-keto esters are reacted with hydrogen in the presence of catalysts of the formula LRuX2 where X is halogen, acetate, allyl, methallyl, 2-phenylallyl, perchlorate, trifluoroacetate, tetrafluoroborate, hexafluoroanti...

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Bibliographische Detailangaben
Hauptverfasser:	HOLZ, JENS, VOSS, GUDRUN, STURMER, RAINER, BORMER, ARMIN, KLATT, MARTIN JOCHEN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	Enantiomerically pure .beta.-hydroxy esters are prepared by a process in which .beta.-keto esters are reacted with hydrogen in the presence of catalysts of the formula LRuX2 where X is halogen, acetate, allyl, methallyl, 2-phenylallyl, perchlorate, trifluoroacetate, tetrafluoroborate, hexafluoroantimonate, hexafluorophosphate, hexafluoroarsenate or trichloroacetate, L is a bidentate phospholane of the formula I where B = a bridging link with 1 - 5 carbon atoms between the two phosphorus atoms, R1 = H, C1 - C6-alkyl, aryl, alkylaryl or SiR2 3, R2 = alkyl or aryl, m = 0 or 1, R3 = H or OR4, and R4 = R1, with the proviso that if m= 1 then R3 = H and if m = 0 then R3 .noteq. H.