DRUG FOR TREATING ABNORMALITIES IN BONE MARROW

Remedies for intramedullary diseases which are efficacious in correcting intramedullary biological balance, in particular, preventing inflammatory cellular infiltration and preventing increase in cell proliferation factors. These remedies contain as the active ingredient methanebisphosphonic acid derivatives, esters thereof, pharmaceutically acceptable salts thereof or hydrates of the same. Because of showing excellent therapeutic effects on intramedullary diseases, the above derivatives are expected as useful in preventing and treating intramedullary diseases such as rheumatoid arthritis, multiple myeloma and osteomyelitis. These compounds are also expected as useful in preventing and treating diseases of the hematopoietic system such as aplastic anemia and myelocytic leukemia.