EXPRESSION IN YEAST OF ANTIGENICALLY ACTIVE, RECOMBINANT HYBRID GLUTAMIC ACID DECARBOXYLASE

An antigenically active hybrid glutamic acid decarboxylase (GAD) comprising an amino-terminal moiety derived from the GAD67 isoform linked directly or indirectly with a middle and carboxy-terminal moiety derived from the GAD65 isoform, and production thereof as a recombinant protein by expression in...

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Bibliographische Detailangaben
Hauptverfasser: CORNER, BRIAN, MACKAY, IAN REAY, LAW, RUBY, TEOH, KHAY-LIN, ZIMMET, PAUL ZEV, ROWLEY, MERRILL JOY
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:An antigenically active hybrid glutamic acid decarboxylase (GAD) comprising an amino-terminal moiety derived from the GAD67 isoform linked directly or indirectly with a middle and carboxy-terminal moiety derived from the GAD65 isoform, and production thereof as a recombinant protein by expression in eukaryotic host cells, particularly yeasts.