AZELASTINE HYDROCHLORIDE-CONTAINING PERCUTANEOUS PREPARATIONHAVING GOOD PERCUTANEOUS ABSORBABILITY AND REDUCED SKIN IRRITATION

A percutaneous preparation which comprises: 0.001 to 5 weight % of azelasti ne hydrochloride; 10 to 97 weight % of at least one hydrocarbon and/or beeswax, wherein said hydrocarbon is selected from the group consisting of white petrolatum, yellow petrolatum, and gelatinized hydrocarbon; 0.5 to 35 we...

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Bibliographische Detailangaben
Hauptverfasser: MIZOBUCHI, NORIKO, SETO, SAYURI
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:A percutaneous preparation which comprises: 0.001 to 5 weight % of azelasti ne hydrochloride; 10 to 97 weight % of at least one hydrocarbon and/or beeswax, wherein said hydrocarbon is selected from the group consisting of white petrolatum, yellow petrolatum, and gelatinized hydrocarbon; 0.5 to 35 weight % of at lea st one higher alcohol and/or polyhydric alcohol, wherein said higher alcohol is selected from the group consisting of stearyl alcohol, cetanol, and cetostearyl alcohol, a nd wherein said polyhydric alcohol is selected from the group consisting of propylene glycol and polyethylene glycol; and 0.5 to 10 weight % of at least one surfactant selected from the group consisting of polyoxyethylene hydrogenated castor oil, glycerol monostearate, polyoxyethylene lauryl ether and cholesterol; and wherein said composition does not contain a fatty acid having 8 or more carbon atoms. Has a reduced skin irritation and good percutaneous absorbability of azelastine hydrochloride (active ingredient).