A HUMAN RADIORESISTANCE/CELL CYCLE PROGRESSION GENE

This invention provides isolated nucleic acids which encode a wildtype and a mutant human homolog of RAD9. This invention also provides purified and mutant wildtype human homologs of RAD9. This invention also provides methods for determining whether a subject has radiosensitivity; for predicting the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DAVEY, SCOTT K, LIEBERMAN, HOWARD B, HOPKINS, KEVIN M
Format: Patent
Sprache:eng ; fre
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Beschreibung
Zusammenfassung:This invention provides isolated nucleic acids which encode a wildtype and a mutant human homolog of RAD9. This invention also provides purified and mutant wildtype human homologs of RAD9. This invention also provides methods for determining whether a subject has radiosensitivity; for predicting the effect of radiation therapy or chemotherapy on a subject; for detecting whether a subject has a predisposition to cancer; for treating a subject who is radiosensitive and for preventing or treating cancer in a subject who is radiosensitive. This invention further provides a method of detecting cervical carcinoma in a subject.