NT-3 AND BDNF ANALOGS HAVING IMPROVED CIRCULATING LIFE AND/OR ABSORPTION

The in vivo circulating life and/or absorption of cationic therapeutic proteins, including but not limited to basic proteins such as NT-3 and BDNF, can be increased by generating analogs that have a lower isoelectr ic point and, preferably, also a lower protein charge relative to the protein of nati...

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Hauptverfasser:	HERSHENSON, SUSAN IRENE, YOUNG, JOHN DAVID, CHEUNG, ELLEN NGOI YIN, BOONE, THOMAS CHARLES
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	The in vivo circulating life and/or absorption of cationic therapeutic proteins, including but not limited to basic proteins such as NT-3 and BDNF, can be increased by generating analogs that have a lower isoelectr ic point and, preferably, also a lower protein charge relative to the protein of native sequence.