METHOD FOR IMPROVING THE PERFORMANCE OF AN IMMUNOREAGENT IN AN IMMUNOASSAY

METHOD FOR IMPROVING THE PERFORMANCE OF AN IMMUNOREAGENT IN AN IMMUNOASSAY

A method for increasing the binding activity of specific binding members bound to a solid phase material, e.g., a particle, that has been sterically stabilized. This increase in binding activity is brought about by degrading a steric stabilizer on the surface of the solid phase material. The method...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SUBOTICH, DANIEL T, JOSEPH, MARY K, POPE, MARK R, PRY, TERRY A, PUTMAN, C. BRENT, MEES, DAVID R, TARCHA, PETER J
Format: Patent
Sprache:eng ; fre
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:A method for increasing the binding activity of specific binding members bound to a solid phase material, e.g., a particle, that has been sterically stabilized. This increase in binding activity is brought about by degrading a steric stabilizer on the surface of the solid phase material. The method involves both immobilizing a specific binding member on the surface of a solid phase material and degrading a steric stabilizer on the surface of that solid phase material. In the preferred embodiment, the method involves the immobilization of a specific binding member on the surface of the sterically stabilized solid phase material, with subsequent degradation of the steric stabilizer.