MAGNETIC RESONANCE BLOOD POOL AGENTS BOUND TO HUMAN SERUM ALBUMIN

The present invention provides compositions comprising a contrast agent capable of reversibly binding to thiol groups of blood-borne proteins. The compositions of the invention provide increased residence time of the contrast agent in the vasculature, thus providing effective blood pool contrast age...

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Bibliographische Detailangaben
Hauptverfasser:	HYNES, MICHAEL R, WALLACE, REBECCA ABERNATHY, MOORE, DENNIS A, COOPER, STEPHEN R
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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Beschreibung
Zusammenfassung:	The present invention provides compositions comprising a contrast agent capable of reversibly binding to thiol groups of blood-borne proteins. The compositions of the invention provide increased residence time of the contrast agent in the vasculature, thus providing effective blood pool contrast agents. The invention also provides methods for imaging a patient comprising administering a composition of the invention and obtaining an image. Compositions comprenant un agent de contraste apte à se lier de manière réversible aux groupes thiol des protéines véhiculées par le sang. Ces compositions offrent un temps de résidence accru de l'agent de contraste dans le réseau sanguin, fournissant ainsi des agents de contraste efficaces pour le pool sanguin. L'invention porte également sur des méthodes de visualisation du corps d'un patient consistant à administrer une composition de cette invention pour obtenir l'image.