DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS

A compound having structure (I) wherein (a) n is from 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO2; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from about 3 to about 7 atoms; (d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; (e) R1 is hydrogen or straight, branched or cyclic alkyl, aryl or C(=NH)-NHR4; and (f) R2, R3 and R4 are independently hydrogen, straight, branched or cyclic alkyl having from one to 10 carbon atoms or aryl, R2 or R3 may be bonded together to form a ring having 5 or 6 atoms. Pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.