RECEPTOR-MEDIATED GENE TRANSFER SYSTEM FOR TARGETING TUMOR GENE THERAPY

The invention relates to a gene transfer system binding to a growth factor receptor, comprising 4-element complex gene transfer system consisting of ligand oligopeptide (LOP)/ polycationic polypeptide/endosome release oligopeptide/exogenous DNA or 3- element complex consisting of ligand oligopeptide...

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Bibliographische Detailangaben
Hauptverfasser:	TIAN, PEIKUN, GU, JIANREN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a gene transfer system binding to a growth factor receptor, comprising 4-element complex gene transfer system consisting of ligand oligopeptide (LOP)/ polycationic polypeptide/endosome release oligopeptide/exogenous DNA or 3- element complex consisting of ligand oligopeptide (LOP)/polycationic polypeptide/exogenous DNA. LOP selected from E5, GE7, GV1 and GV2 and constructed as a composite polypeptid e vector can be used to target exogenous genes into malignant tumor cells or tumor vascul ar endothelial cells. They are also able to highly inhibit the growth of tumor cells in animals wh en p15, p16 or p21 WAF-1 is used as the exogenous genes. The invention also allows targetin g two or more types of exogenous genes and transducing exogenous genes to hemopietic, lymphoid, liver, kidney, nerve cells using a specific LOP that can recognize relevant receptors expressed in these cells for gene therapy.