SPECIFIC BINDING MEMBERS FOR HUMAN CARCINOEMBRYONIC ANTIGEN, MATERIALS AND METHODS

Sequence and binding information is provided for particularly advantageous specific binding members which bind human carcinoembryonic antigen (CEA) with a dissociation constant which is less than 1,0 x 10-8M, are substantially noncross-reactive with human liver cells, bind to the A3-B3 extracellular...

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Hauptverfasser:	MCCAFFERTY, JOHN GERALD, OSBOURN, JANE KATHARINE, ALLEN, DEBORAH JULIE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Sequence and binding information is provided for particularly advantageous specific binding members which bind human carcinoembryonic antigen (CEA) with a dissociation constant which is less than 1,0 x 10-8M, are substantially noncross-reactive with human liver cells, bind to the A3-B3 extracellular domain of human carcinoembryonic antigen and/or bind to cell-associated human carcinoembryonic antigen preferentially over soluble human carcinoembryonic antigen. These are useful particularly in determination of CEA expression by cells such as tumour cells.