PROCESSES AND INTERMEDIATES FOR PREPARING 3-(1-PIPERAZINYL)-1,2-BENZISOTHIAZOLE

PROCESSES AND INTERMEDIATES FOR PREPARING 3-(1-PIPERAZINYL)-1,2-BENZISOTHIAZOLE

Disclosed are processes for producing 3-(1- piperazinyl)-1,2-benzisothiazole of the formula: (see formula I) by reacting a compound of the formula: (see formula II) with piperazine at a temperature of 80-170.degree.C. 3-(1- piperazinyl)-1,2-benzisothiazole is useful as an intermediate for producing...

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Bibliographische Detailangaben
Hauptverfasser: SINAY, TERRY G., JR, FOX, DARRELL E, WALINSKY, STANLEY W, LAMBERT, JOHN F
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Disclosed are processes for producing 3-(1- piperazinyl)-1,2-benzisothiazole of the formula: (see formula I) by reacting a compound of the formula: (see formula II) with piperazine at a temperature of 80-170.degree.C. 3-(1- piperazinyl)-1,2-benzisothiazole is useful as an intermediate for producing 5-(2-(4-(1,2-benzisothiazol-3-yl)-1- piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one (ziprasidone) that has neuroleptic activity.