METHODS AND COMPOSITIONS FOR THE DELIVERY OF MONOMERIC PROTEINS

METHODS AND COMPOSITIONS FOR THE DELIVERY OF MONOMERIC PROTEINS

Methods and devices for dissociating multimeric proteins and their delivery to patients, along with resultant compositions, are provided. A monomeric protein delivery device is also provided, comprising a supply of a multimeric protein (4) complex, comprising multimeric protein and an aggregating ag...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VAN ANTWERP, NANNETTE, VAN ANTWERP, WILLIAM P
Format: Patent
Sprache:eng ; fre
Schlagworte:
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Methods and devices for dissociating multimeric proteins and their delivery to patients, along with resultant compositions, are provided. A monomeric protein delivery device is also provided, comprising a supply of a multimeric protein (4) complex, comprising multimeric protein and an aggregating agent; a flow path having a subcutaneous exit (8) , fluidly coupling the multimeric protein supply to the exit; a porous surface assembly situated along the flow path comprising a porous surface (10); and an aggregating agent binding partner carried by the surface (12); whereby the aggreagating agent of the multimeric protei n complex passing along the surface is bound to the binding partner on the surface to create a monomeric protein flow through the subcutaneous exit.