PEPTIDES AND PEPTIDOMIMETICS INHIBITING THE ONCOGENIC ACTION OF P21 RAS

The present invention provides peptides, cyclized peptides and peptidomimetics which inhibit the oncogenic and/or transforming activity of the p21 ras protein, pharmaceutical compositions containing at least one of the rasinhibiting peptides, cyclized peptides and peptidomimetics, and methods for in...

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Bibliographische Detailangaben
Hauptverfasser:	HLAVKA, JOSEPH J, ABAJIAN, HENRY BAXTER, PINCUS, MATTHEW R, NOBLE, JOHN FOWLER, KENDE, ANDREW S
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention provides peptides, cyclized peptides and peptidomimetics which inhibit the oncogenic and/or transforming activity of the p21 ras protein, pharmaceutical compositions containing at least one of the rasinhibiting peptides, cyclized peptides and peptidomimetics, and methods for inhibiting the ras-mediated oncogenic and/or transformation process in mammalian cells or tissues.