COPOLYMERIC MICELLE DRUG COMPOSITION AND METHOD FOR THE PREPARATION THEREOF

A water-soluble micelle-type drug composition carrying paclitaxel, cyclosporin A or adriamycin is found to be particularly effective when it is composed of a water-soluble amphiphilic block copolymer micelle having a hydrophilic poly(alkylene oxide) component and a hydrophobic biodegradable component, and the drug physically trapped in the micelle; wherein the block copolymer is not cross-linked by a cross- linking agent and has a molecular weight of 10,000 daltons or less; the hydrophilic component is 70 wt% or less based on the total weight of the block copolymer; and the hydrophobic component is a biodegradable polymer selected from the group consisting of poly(lactic acid), poly(glycolic acid), poly(lactic-co-glycolic acid), poly(.epsilon.-caprolactone) and a mixture thereof.