CONJUGATES OF A POLYPEPTIDE AND A BIOCOMPATIBLE POLYMER

The present invention relates to a process for improving the in vivo function of a polypeptide by shielding exposed targets of said polypeptide, by immobilizing the polypeptide by interaction with a group-specific adsorbent carrying ligands manufactured by organic-chemical synthesis, activating the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	SMEDS, ANNA-LISA, DALBORG, JOHANNA, SANDBERG, HELENA, AKERBLOM, EVA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a process for improving the in vivo function of a polypeptide by shielding exposed targets of said polypeptide, by immobilizing the polypeptide by interaction with a group-specific adsorbent carrying ligands manufactured by organic-chemical synthesis, activating the biocompatible polymer, conjugating the thus activated biocompatible polymer to the immobilized polypeptide, and thereafter eluting the conjugate from the adsorbent. The present invention further relates to conjugates of a polypeptide and a biocompatible polymer obtainable by the present process, and use of said conjugates as medicaments. Specifically, the polypeptide is factor VIII, the von Willebrand factor or factor IX. The invention is particularly advantageous for conjugates where the polypeptide is factor VIII with a high specific activity using monomethoxy polyalkyleneoxide (mPEG) as the biocompatible polymer.