AZA-ANTHRACYCLINONE DERIVATIVES

AZA-ANTHRACYCLINONE DERIVATIVES

Compounds of formula (I) wherein X1 and X2 are C=O, C=NH or CH2, X3 is CH2, CO, CHOH, formula (III), formula (IV) wherein n=2 or 3, and C=N(R9) wherein R9 is hydroxy or amino-aryl, and each of R1, R 2, R3, R4, R5, R6, R7 and R8 are hydrogen, halogen or an organic residue, are useful in the treatment...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CARUSO, MICHELE, FAIARDI, DANIELA, LANSEN, JACQUELINE, BANDIERA, TIZIANO, SUARATO, ANTONIO
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Beschreibung
Zusammenfassung:Compounds of formula (I) wherein X1 and X2 are C=O, C=NH or CH2, X3 is CH2, CO, CHOH, formula (III), formula (IV) wherein n=2 or 3, and C=N(R9) wherein R9 is hydroxy or amino-aryl, and each of R1, R 2, R3, R4, R5, R6, R7 and R8 are hydrogen, halogen or an organic residue, are useful in the treatment of amyloidosis. A process fo r their preparation and pharmaceutical compositions containing them are also described.