ACELLULAR PERTUSSIS VACCINES AND METHODS OF PREPARATION THEREOF

ACELLULAR PERTUSSIS VACCINES AND METHODS OF PREPARATION THEREOF

A cellular pertussis vaccines comprise purified toxin or toxoid thereof, filamentous haemagglutinin, pertactin and fimbrial agglutinogens formulated to confer protection to at least 70 % of members of an at-risk population. The fimbrial agglutinogens may be prepared from a Bordetella strain, particu...

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Bibliographische Detailangaben
Hauptverfasser: BARRETO, LUIS, VOSE, JOHN R, THIPPHAWONG, JOHN, JACKSON, GAIL E.D, BOUX, LESLIE, FAHIM, RAAFAT E.F, KLEIN, MICHEL H, TAN, LARRY U.L, HERBERT, ANDREW
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:A cellular pertussis vaccines comprise purified toxin or toxoid thereof, filamentous haemagglutinin, pertactin and fimbrial agglutinogens formulated to confer protection to at least 70 % of members of an at-risk population. The fimbrial agglutinogens may be prepared from a Bordetella strain, particularly a B. pertussis strain by a multiple step procedure involving extraction of the fimbrial agglutinogens from cell paste and concentrating and purifying the extracted material.