USE OF SUBSTITUTED ARYL-MORPHOLINO-, THIOMORPHOLINO-OR PIPERAZINO-PROPANONES FOR THE TREATMENT OF PREVENTION OF ALZHEIMER'S DISEASE

Disclosed are compounds of formula (I), wherein X is selected from oxygen, sulfur and NR; wherein R is selected from hydrogen, lower alkyl and CH2CH2COAr1; and Z is hydrogen; straight or branched chain alkyl having 1-6 carbon atoms; or Z and R1, R2 or R3 together represent CH2; CH2CH2; CH2O; or CH2S forming a five or six membered ring and such ring may be optionally substituted with lower alkyl or phenyl; R24 is hydrogen; lower alkyl, or optionally substituted phenyl; each R10 is selected from hydrogen and lower alkyl; and Ar1 represents an aryl group or optionally substituted phenyl, thienyl or optionally substituted thienyl; or the pharmaceutically acceptable salts thereof, useful for preventing or decreasing the production of abnormally phosphorylated paired helical filament (PHF) epitopes associated with Alzheimer's Disease and, therefore, useful for treating Alzheimer's Disease.