A NEW PHYSICALLY STABLE SOLID FORM OF A FLUOROQUINOLONE

Novel crystal forms of the fluoroquinolone, ¢S-(R*,S*)!-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-¢3-¢1-(methylamino)ethyl!-1-pyrrolidinyl!-4-oxo-3-quinolinecarboxylic acid are disclosed. The forms are characterized by one methanol solvate form, and three anhydrous polymorphic forms, of which,...

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Hauptverfasser:	SCHINZER, WILLIAM C, ALDRICH, DALE S, DUNN, MICHAEL J, CHAO, ROBERT SHIH-LIANG, YU, XUANQIANG, JEGANATHAN, AZHWARSAMY, BERGREN, MICHAEL S
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Novel crystal forms of the fluoroquinolone, ¢S-(R,S)!-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-¢3-¢1-(methylamino)ethyl!-1-pyrrolidinyl!-4-oxo-3-quinolinecarboxylic acid are disclosed. The forms are characterized by one methanol solvate form, and three anhydrous polymorphic forms, of which, Form III exhibits greatest stability and decreased hygroscopicity.