DRUG FOR TUMOR GROWTH SUPPRESSION

The invention relates to the field of biology and medicine, in particul ar to suppression of the growth of malignant tumors. The object of the present invention is to find more effective and less toxic drugs for suppression of tumor growth. The essence of the proposed invention is that in order to s...

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Hauptverfasser:	ZHUKOVA, OLGA STEPANOVNA, TRESCHALINA, ELENA MIKHAILOVNA, VOLPIN, MARK EFIMOVICH, NOVODAROVA, GALINA NIKOLAEVNA, VOROZHTSOV, GEORGY NIKOLAEVICH, KAZACHKINA, NATALYA IVANOVNA, YAKUBOVSKAYA, RAISA IVANOVNA, SYRKIN, ANATOLY BORISOVICH, GERASIMOVA, GALINA KONSTANTINOVNA, LEVITIN, ILYA YAKOVLEVICH, KALIA, OLEG LEONIDOVICH, CHISSOV, VALERY IVANOVICH, LUKIYANETS, EVGENY ANTONOVICH, LUZHKOV, JURY MIKHAILOVICH, KRAINOVA, NADEZHDA JURIEVNA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to the field of biology and medicine, in particul ar to suppression of the growth of malignant tumors. The object of the present invention is to find more effective and less toxic drugs for suppression of tumor growth. The essence of the proposed invention is that in order to suppress tumo r growth, a drug consisting of a biogenic reductant and a complex of cobalt or iron with substituted phthalocyanines (I) or naphthalocyanines (II) is used. (see formula I , II) where R = COONa, SO3Na, CH2C5H5N~C1-, CH2(NH2)2S~CC1-. Use of the proposed drug makes it possible to suppress effectively the growth of a wide range of malignant tumors, in particular to achieve the suppression of proliferation of cancer cells (in vitro), inhibition of the growth of tumors in mice (in vivo) and a substantial increase in their life-span, including that obtained in comparison with use of the prototype.