METHOD FOR THE PREPARATION OF STEROID DERIVATIVE KETAL

METHOD FOR THE PREPARATION OF STEROID DERIVATIVE KETAL

The invention relates to a method of the preparation of a steroid derivative ketal according to the general formula I: (see figure I) wherein R; is CH3 or C~H5; R2 is OH; R3 is H, CH3; C.ident.CH, CH2Hal,, or CH2CN; or R2 and R3 together are O; R4 is (2-5C) alkylene; and Hal is Cl, Br or I, characte...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VRIJHOF, PIETER, BRANDS, FRANCISCUS THEODORUS LEONARDUS
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Beschreibung
Zusammenfassung:The invention relates to a method of the preparation of a steroid derivative ketal according to the general formula I: (see figure I) wherein R; is CH3 or C~H5; R2 is OH; R3 is H, CH3; C.ident.CH, CH2Hal,, or CH2CN; or R2 and R3 together are O; R4 is (2-5C) alkylene; and Hal is Cl, Br or I, characterized in that the compound of formula II: (see figure II) wherein R1, R2 and R3 have the previously given meanings, is treated in the presence of an orthoester of formula III: (see figure III) or an orthoester of formula IV: (see figure IV) wherein R4 has the previously indicated meaningor a mixture thereof with an alcohol according to the general formula HOR4OH, wherein R4 has the previously given meaning.