PHARMACEUTICAL FORMULATIONS FOR TREATING DUST MITE ALLERGY

The present invention provides novel therapeutic compositions and multipeptide formulations of peptides and modified peptides of Group I and Group II Der p and Der f derived protein allergens. Such novel therapeutic compositions and multipeptide formulations ar e the result of a preformulation scheme to develop an optimized drug product for therapeutic treatment of humans suffering from allerg y to house dust mite allergens. The Der p and Der f peptides and modified peptides in accordance with the invention possess certain uniqu e characteristics which render them particularly suitable for drug product formulation. Therapeutic compositions and multipeptide form ulations of the invention have been optimized to accommodate and maintain the unique characteristics of the peptides and modified peptides de rived from house dust mite protein allergens and at the same time provide maximum therapeutic effect when used in therapeutic regimens for the treatment of house dust mite allergy in humans. The invention further provides novel modified peptides derived from Der p I and Der p II protein allergens.