PREPARATION OF SUBSTITUTED THIAZOLES

PREPARATION OF SUBSTITUTED THIAZOLES

A process for the preparation of a substituted thiazole comprises reacting an isothiocyanate compound of the general formula Hal.CH(R1). CH=C(R2).NCS in which Hal is a chlorine or bromine atom and R and R2 is each a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, in solution with a c...

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Bibliographische Detailangaben
Hauptverfasser: JACKSON, ARTHUR, HEYES, GRAHAM, GRAYSON, JAMES IAN, CLARKE, RUSSELL
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process for the preparation of a substituted thiazole comprises reacting an isothiocyanate compound of the general formula Hal.CH(R1). CH=C(R2).NCS in which Hal is a chlorine or bromine atom and R and R2 is each a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, in solution with a chlorinating or brominating agent. The compound 2-chloro-5-(chloromethyl) thiazole, which is an important intermediate in the manufacture of agrochemical and pharmaceutical products, may very advantageously be prepared by this method.