MICROBIOLOGICAL PROCESS FOR THE PREPARATION OF HETEROAROMATIC CARBOXYLIC ACIDS USING MICROORGANISMS OF THE GENUS ALCALIGENES

A microbiological process for the preparation of heteroaromatic carboxylic acids or physiologically tolerated salts thereof, of the general formulae: in which R1 and R2 are identical or different and denote a hydrogen or halogen atom and X denotes a nitrogen atom or -CH-, is described herein. The co...

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Hauptverfasser:	RODUIT, JEAN-PAUL, GLOCKLER, RAINER, KIENER, ANDREAS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PROCESSES USING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A microbiological process for the preparation of heteroaromatic carboxylic acids or physiologically tolerated salts thereof, of the general formulae: in which R1 and R2 are identical or different and denote a hydrogen or halogen atom and X denotes a nitrogen atom or -CH-, is described herein. The conversion is carried out in such a way that heteroaromatic nitriles of the general formulae: in which R1, R2 and X are as previously defined, are converted as substrate, using 2-cyanopyridine-utilizing microorganisms of the genus Alcaligenes which have been cultured before the biotransformation in the presence of a dicarboxylic acid, tricarboxylic acid or a carbohydrate, into the corresponding carboxylic acid, and the latter is converted where appropriate into a physiologically tolerated salt thereof.