IMPROVED PROCESS FOR THE SYNTHESIS OF 2-AMINO-3,5-DIHYDRO-7-SUBSTITUTED-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONES

IMPROVED PROCESS FOR THE SYNTHESIS OF 2-AMINO-3,5-DIHYDRO-7-SUBSTITUTED-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONES

An improved process for the preparation of 2-amino-3,5-dihydro-7-substituted-4H-pyrrolo¢3,2-d!pyrimidin-4-ones is described wherein 2,6-diamino-3,5-dihydro-7-substitued-4H-pyrrolo¢3,2-d!pyrrimidin-4-one is converted to a diazonium salt which is subsequently catalytically reduced to the desired compo...

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Bibliographische Detailangaben
Hauptverfasser: ZELLER, JAMES ROBERT, DE JONG, RANDALL LEE, SEAMANS, RONALD EVERETT
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:An improved process for the preparation of 2-amino-3,5-dihydro-7-substituted-4H-pyrrolo¢3,2-d!pyrimidin-4-ones is described wherein 2,6-diamino-3,5-dihydro-7-substitued-4H-pyrrolo¢3,2-d!pyrrimidin-4-one is converted to a diazonium salt which is subsequently catalytically reduced to the desired compound, as Well as valuable intermediates used in the process.