PHARMACEUTICALLY ACCEPTABLE POLYMERIC TISSUE COATING

Described herein is a multi-functional polymeric material for use in inhibit ing adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the poly meric material adsorbs well to cells or tissue, and the other component of the polymeric mat...

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Bibliographische Detailangaben
Hauptverfasser:	HUBBELL, JEFFREY A, SAWHNEY, AMARPREET S, HILL-WEST, JENNIFER L, CHOWDHURY, SANGHAMITRA M, DRUMHELLER, PAUL D, ELBERT, DONALD
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ADHESIVES CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMICAL PAINT OR INK REMOVERS CHEMISTRY COATING COMPOSITIONS, e.g. PAINTS, VARNISHES ORLACQUERS COMPOSITIONS BASED THEREON COMPOSITIONS OF MACROMOLECULAR COMPOUNDS CORRECTING FLUIDS DISINFECTION, STERILISATION, OR DEODORISATION OF AIR DYES FILLING PASTES HUMAN NECESSITIES HYGIENE INKS MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL MISCELLANEOUS APPLICATIONS OF MATERIALS MISCELLANEOUS COMPOSITIONS NATURAL RESINS ORGANIC MACROMOLECULAR COMPOUNDS PAINTS PASTES OR SOLIDS FOR COLOURING OR PRINTING POLISHES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP USE OF MATERIALS THEREFOR WOODSTAINS
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Beschreibung
Zusammenfassung:	Described herein is a multi-functional polymeric material for use in inhibit ing adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the poly meric material adsorbs well to cells or tissue, and the other component of the polymeric material does not adsorb well to tissues. A water -soluble polymer that does not bear charge (polynonion) and which is not poly(ethylene glycol) is used as the non-binding component. A water-soluble polymer that is positively charged at physiological pH (polycation) and which is not poly(L-lysine) is used as the tissue binding component. When the bi-functional polyme ric material contacts a tissue, the tissue-binding component binds and thus immo bilizes the attached non-binding component, which will t hen extend generally away from the tissue surface and sterically block the attac hment of other tissues. The method and compositions are useful in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells.