G CAP-STABILIZED OLIGONUCLEOTIDES

The invention relates to oligonucleotides of the formula 5'-(CAP)-(oligo)-(CAP)-3 where (Oligo) is a nucleotide sequence of from 10 to 40 nucleotides in length, and CAP is Gm, where m is an integer of from zero to ten, preferably of from two to six, particularly preferably of from three to five...

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Bibliographische Detailangaben
Hauptverfasser:	UHLMANN, EUGEN, PEYMAN, ANUSCHIRWAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to oligonucleotides of the formula 5'-(CAP)-(oligo)-(CAP)-3 where (Oligo) is a nucleotide sequence of from 10 to 40 nucleotides in length, and CAP is Gm, where m is an integer of from zero to ten, preferably of from two to six, particularly preferably of from three to five and very particularly preferably four, and where the two CAP's which are present in the molecule can be defined independently of each other and must be different in the case where m is zero at the 5' or 3' end and the end of the "Oligo" sequence is not formed by a guanine, to a process for their preparation, to pharmaceuticals con-taining the novel oligonucleotides, and to their use for preparing a pharmaceutical for treating diseases or for preparing a diagnostic agent.