AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH

The present patent application discloses compounds having the formula or a pharmaceutically acceptable salt thereof wherein R1 is hydrogen, alkyl or benzyl; X is O or NOR2, wherein R2 is hydrogen, alkyl or benzyl; Y is N-R4 wherein R4 is hydrogen, OH or alkyl; n is 0 or 1; R6 is phenyl, naphthyl, th...

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Hauptverfasser: WATJEN, FRANK, DREJER, JORGEN
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:The present patent application discloses compounds having the formula or a pharmaceutically acceptable salt thereof wherein R1 is hydrogen, alkyl or benzyl; X is O or NOR2, wherein R2 is hydrogen, alkyl or benzyl; Y is N-R4 wherein R4 is hydrogen, OH or alkyl; n is 0 or 1; R6 is phenyl, naphthyl, thienyl, pyridyl, all of which may be substituted one or more times with substituents selected from the group consisting or halogen, CF3, NO2, amino, alkyl, alkoxy and phenyl; A is a ring of five to seven atoms fused with the benzo ring at the position s marked a and b. The compounds are useful in the treatment of cerebrovascular disorders f or example.