PHOSPHONOSULFONATE SQUALENE SYNTHETASE INHIBITOR SALTS AND METHOD

PHOSPHONOSULFONATE SQUALENE SYNTHETASE INHIBITOR SALTS AND METHOD

New salt forms of the phosphonosulfonate squalene synthetase inhibitor are provided which include the calcium, the t-butylamine salt, t-octylamine salt and the dehydroabietylamine salt. These salts inhibit cholesterol biosynthesis and therefore are used in lowering serum cholesterol and in treating...

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Bibliographische Detailangaben
Hauptverfasser: THOTTAHIL, JOHN K, PENDRI, YADAGIRI, KUCERA, DAVID J, CHEN, CHUNG-PIN, MARTINEZ, EDUARDO J, PANSEGRAU, PAUL D, TIMMINS, PETER
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:New salt forms of the phosphonosulfonate squalene synthetase inhibitor are provided which include the calcium, the t-butylamine salt, t-octylamine salt and the dehydroabietylamine salt. These salts inhibit cholesterol biosynthesis and therefore are used in lowering serum cholesterol and in treating atherosclerosis.