METHODS FOR THE DIAGNOSIS OF DIABETES AND PREDIABETIC CONDITIONS

A method for detecting a autoantibodies to glutamic acid decarboxylase (GAD) in the serum of a patient as diagnostic of a diabetic or prediabetic condition in the patient, comprises contacting a serum sample from the patient with a GAD antigen and detecting binding of autoantibodies to GAD in the sa...

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Bibliographische Detailangaben
Hauptverfasser: MACKAY, IAN REAY, ZIMMET, PAUL ZEV, ROWLEY, MERRILL JOY
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:A method for detecting a autoantibodies to glutamic acid decarboxylase (GAD) in the serum of a patient as diagnostic of a diabetic or prediabetic condition in the patient, comprises contacting a serum sample from the patient with a GAD antigen and detecting binding of autoantibodies to GAD in the sample by the GAD antigen, wherein the GAD antigen comprises a GAD preparation containing an enhanced amount of dimer(s) or oligomer(s) of the 65 kD and/or 67 kD isoforms of GAD. A diagnostic kit is also disclosed.