STABILIZED MEDICINAL AEROSOL SOLUTION FORMULATION

STABILIZED MEDICINAL AEROSOL SOLUTION FORMULATION

Stabilized medicinal aerosol solution formulations comprising medicaments th at degrade or decompose by interaction with solvents or water, an HFC propellent, a cosolvent and an acid are described. Further, specific medicinal aerosol solution formulations comprising ipratropium bromide or fenoterol,...

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Bibliographische Detailangaben
Hauptverfasser: KONTNY, MARK JAMES, JAGER, PAUL DONALD, NAGEL, JURGEN H
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Stabilized medicinal aerosol solution formulations comprising medicaments th at degrade or decompose by interaction with solvents or water, an HFC propellent, a cosolvent and an acid are described. Further, specific medicinal aerosol solution formulations comprising ipratropium bromide or fenoterol, ethyl alcohol, 1,1,1,2-tetrafluoroethane o r 1,1,1,2,3,3,3-heptafluoropropane, and either an inorganic acid or an organic acid are described. The acids ace present in amounts sufficien t to reduce the degradation of the medicaments to acceptable levels.