PROCESS FOR THE PREPARATION OF 5-FORMYLAMINOPYRIMIDINES

The present invention provides a process for the preparation of 5-formylaminopyrimidines of the general formula:- (I) in which R1, R2 and R3 are the same or different and signify H, OH, SH, NH2, alkylamino, halogen, O-alkyl, S-alkyl or alkyl, as well as aryl, and alkyl is an aliphatic radical contai...

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Bibliographische Detailangaben
Hauptverfasser:	GRAEFE, JUERGEN, THALHAMMER, FRANZ
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	The present invention provides a process for the preparation of 5-formylaminopyrimidines of the general formula:- (I) in which R1, R2 and R3 are the same or different and signify H, OH, SH, NH2, alkylamino, halogen, O-alkyl, S-alkyl or alkyl, as well as aryl, and alkyl is an aliphatic radical containing up to 4 carbon atoms, from the corresponding 5-nitrosopyrimidines of the general formula:- in which R1, R2 and R3 have the same meanings as above, wherein the starting compound is subjected to a reductive formylation in the presence of a noble metal catalyst, as well as of formic acid and of a,salt thereof. In this way, with low technical expense, it is possible to prepare 5-formylaminopyrimidines with a yield of up to 98% and with a degree of purity of more than 98%.