IMPROVED PROCESS FOR THE SYNTHESIS OF 2,6-DICHLORO-5-FLUORONICOTINIC ACID AND 2,6-DICHLORO-5-FLUORONICOTINOYL CHLORIDE
An improved process for the preparation of 2,6-dichloro-5-fluoronicotinoyl chloride is described where a 2,6-dihydroxy- 5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro-5-fluor- onicotinoyl chloride and subsequent basic hydrolys...
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| Format: | Patent |
| Sprache: | eng ; fre |
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| Zusammenfassung: | An improved process for the preparation of 2,6-dichloro-5-fluoronicotinoyl chloride is described where a 2,6-dihydroxy- 5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro-5-fluor- onicotinoyl chloride and subsequent basic hydrolysis affords 2,6-dichloro-5- fluoronicotinic acid. |
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