4-AMINO-N-(4-METHYL-4-PIPERIDINYL)-2-METHOXYBENZAMIDES

4-AMINO-N-(4-METHYL-4-PIPERIDINYL)-2-METHOXYBENZAMIDES

Piperidinyl substituted benzamides of formula (I) the pharmaceutically acceptable acid addition salts thereof and the stereoisomeric forms thereof, wherein R1 is hydrogen or halo; R2 is halo; R3 is hydrogen or halo; R4 and R5 each independently are hydrogen, C1-4alkyl or haloC1-4alkyl; and the group...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VAN DAELE, GEORGES H. P, LEYSEN, JOSEPHA E. M. F
Format: Patent
Sprache:eng ; fre
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
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Beschreibung
Zusammenfassung:Piperidinyl substituted benzamides of formula (I) the pharmaceutically acceptable acid addition salts thereof and the stereoisomeric forms thereof, wherein R1 is hydrogen or halo; R2 is halo; R3 is hydrogen or halo; R4 and R5 each independently are hydrogen, C1-4alkyl or haloC1-4alkyl; and the group NR4R5 may also be azido, Alk is C2-4alkanediyl; pharmaceutical compositions containing said compounds of formula (I) as active ingredient; use of said compounds as a medicine; process of preparing said compounds; compounds of formula (I) containing a radioacti ve isotope; process of marking 5HT2-receptor sites; and process for imaging an organ are disclosed.