OCTACARBOXY SUBSTITUTED TETRA(2,3-PYRAZINO)PORPHYRAZINES ANDTHEIR DERIVATIVES

Disclosed herein are water-soluble octacarboxy substituted tetra(2,3pyrazino)porphyrazines of the following formula: (I) wherein M is HH, Cu, VO, Co, Ni or Zn; and R is C2H5, n-C4H9, n-C6H13, n-C8H17 or ONa. The present invention discloses photoinactivators and more particularly a novel class of wat...

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Bibliographische Detailangaben
Hauptverfasser:	VAN LIER, JOHANNES E, KUDREVICH, SVETLANA V, GALPERN, MARIA G
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Disclosed herein are water-soluble octacarboxy substituted tetra(2,3pyrazino)porphyrazines of the following formula: (I) wherein M is HH, Cu, VO, Co, Ni or Zn; and R is C2H5, n-C4H9, n-C6H13, n-C8H17 or ONa. The present invention discloses photoinactivators and more particularly a novel class of water soluble azaphathalocyanines (AzaPc's), functionalized on the macrocyle with carboxy substituents to yield octacarboxy substituted tetra(2,3pyrazino)porphyrazines (TTPA's). The invention also relates to processes for their preparation and the use thereof for the photodynamic therapy of cancer and the inactivation of viruses or bacteria in stored blood products.