PROCESS FOR THE ISOLATION AND PURIFICATION OF MEVINOLIN

In a process for preparing mevinolin by fermentation of a biomass in a fermentation liquor, which includes dissolving mevinolin from the biomass into the fermentation liquor, and separating the biomass from the fermentation liquor to obtain a separated fermentation liquor, separating the mevinolin f...

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Hauptverfasser: BAGDI, ILONA, BALINT, JANOS, SZEKELY, IMRE, KERI, VILMOS, ILKOY, EVA, HOGYE, IRMA, HORVATH, GYULA, SZTARAY, ZSUZSANNA, MATYAS, SZABOLCS, ANDOR, ATTILA, MORAVCSIK, IMRE, SZABO, CSABA, DEAK, LAJOS, JAKAB, ATTILA, SCHEIDL, ZSUZSANNA, SZABO, ISTVAN, LANG, ILDIKO, DELI, ETELKA, ESZENYI, LASZLO, AMBRUS, GABOR, KOVACS, VERA, JEKKEL, ANTONIA
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:In a process for preparing mevinolin by fermentation of a biomass in a fermentation liquor, which includes dissolving mevinolin from the biomass into the fermentation liquor, and separating the biomass from the fermentation liquor to obtain a separated fermentation liquor, separating the mevinolin from the separated fermentation liquor, and recovering the end product, the improvement which comprises carryingout the dissolving at a pH between about 7.5 and about 10, and the separating of the mevinolin is carried out at a pH between about 4.5 and about 1.