NOVEL SUBSTITUTED SALICYLIC ACIDS

NOVEL SUBSTITUTED SALICYLIC ACIDS

A compound of the formula Het-NR-SO2-Ph2-A-Ph1 (COOH)(OH) and tautomic form, salts, solvates, C1-6 alkyl esters and pharmaceutical compositions of the compound. Ph1 and Ph2 are benzene rin gs with the proviso that carboxy and hy- droxy are ortho to one another. Het includes an optionally substituted...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: AHRGREN, LEIF, AGBACK, KARL HUBERT, SMEDEGARD, GORAN, HARALDSSON, MARTIN, BERGLINDH, THOMAS, OLSSON, LARSE
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A compound of the formula Het-NR-SO2-Ph2-A-Ph1 (COOH)(OH) and tautomic form, salts, solvates, C1-6 alkyl esters and pharmaceutical compositions of the compound. Ph1 and Ph2 are benzene rin gs with the proviso that carboxy and hy- droxy are ortho to one another. Het includes an optionally substituted heterocyclic ring which includes conjugated double bonds and binds to nitrogen in NR. The compound is characterized in that A i s a bridge which is stable against reduction because it is not azo, and in that R is hydrogen or lower alkyl. The inventi on also includes the preparation of the compound and its use as a drug, particularly for treating autoimmune diseases.