1,3-DIHYDRO-2H-IMIDAZO(4,5-B) QUINOLIN-2-ONE DERIVATIVES

Novel 1,3-dihydro-2H-imidazo(4,5-b)quinolin-2-one derivatives of formu- la (I) wherein R is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl optionally s ub- stituted with from 1 to 3 substituents each independently selected from halo , hydroxy, C1-6alkyloxy, C5-6cycloalkyloxy, C1-6alkyl or trifluorometh...

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Bibliographische Detailangaben
Hauptverfasser:	FREYNE, EDDY J. E, DE CHAFFOY DE COURCELLES, DIDIER R. G. G, RAEYMAEKERS, ALFONS H. M
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Novel 1,3-dihydro-2H-imidazo(4,5-b)quinolin-2-one derivatives of formu- la (I) wherein R is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl optionally s ub- stituted with from 1 to 3 substituents each independently selected from halo , hydroxy, C1-6alkyloxy, C5-6cycloalkyloxy, C1-6alkyl or trifluoromethyl; pyr- idinyl; thienyl optionally substituted with halo or C1-6alkyl; and (.alpha.) is a radi- cal of formula (a), (b), or (c); the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, said compounds being potent inhibitors of both phosphodiesterase III and IV, which are useful in the treatment of aller- gic disorders, atopic diseases and related afflictions. Intermediates in the prepar- ation thereof. Pharmaceutical compositions containing said compounds as an active ingredient. Methods of preparing said compounds and pharmaceutical compositions.