DECAHYDROISOQUINOLINES AS EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS

This invention provides novel decahydroisoquinoline compounds of the formula (See formula I) which are useful as excitatory amino acid receptor antagonists and in the treatment of neuroglogical disorders. This invention also provides synthetic methods for preparing decahydroisoquinolines, as well as...

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Hauptverfasser: ARNOLD, MACKLIN BRIAN, HANSEN, MARVIN MARTIN, SCHOEPP, DARRYLE DARWIN, AUGENSTEIN, NANCY KAY, ORNSTEIN, PAUL LESLIE, MARTINELLI, MICHAEL JOHN, BERTSCH, CARL FRANKLIN, HARKNESS, ALLEN ROBERT, HUFF, BRET EUGENE, LUNN, WILLIAM HENRY WALKER
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creator ARNOLD, MACKLIN BRIAN
HANSEN, MARVIN MARTIN
SCHOEPP, DARRYLE DARWIN
AUGENSTEIN, NANCY KAY
ORNSTEIN, PAUL LESLIE
MARTINELLI, MICHAEL JOHN
BERTSCH, CARL FRANKLIN
HARKNESS, ALLEN ROBERT
HUFF, BRET EUGENE
LUNN, WILLIAM HENRY WALKER
description This invention provides novel decahydroisoquinoline compounds of the formula (See formula I) which are useful as excitatory amino acid receptor antagonists and in the treatment of neuroglogical disorders. This invention also provides synthetic methods for preparing decahydroisoquinolines, as well as, novel intermediates in the synthesis thereof.
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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title DECAHYDROISOQUINOLINES AS EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS
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