TARGETED DELIVERY OF BONE GROWTH FACTORS

TARGETED DELIVERY OF BONE GROWTH FACTORS

2102808 9220371 PCTABS00017 Methods and compositions for using conjugates of bone growth factors and targeting molecules in bone repair and augmentation are provided. The bone growth factor and targeting molecule are chemically conjugated to a crosslinker. The crosslinker is preferably a synthetic h...

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Bibliographische Detailangaben
Hauptverfasser: BENTZ, HANNE, ROSEN, DAVID
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:2102808 9220371 PCTABS00017 Methods and compositions for using conjugates of bone growth factors and targeting molecules in bone repair and augmentation are provided. The bone growth factor and targeting molecule are chemically conjugated to a crosslinker. The crosslinker is preferably a synthetic hydrophilic polymer. The bone growth factor is preferably TGF-.beta., activin, or bone morphogenic protein (BMP). Targeting molecules preferably have an affinity for bone, such as tetracycline, calcein, bisphosphonate, polyaspartic acid, polyglutamic acid, aminophosphosugars, or estrogen.