MICROBIOLOGICAL PROCESS FOR PREPARING MEVINOLIN

MICROBIOLOGICAL PROCESS FOR PREPARING MEVINOLIN

The invention refers to a new a microbial process for preparing .beta.,.delta.-d ihydroxy-7-¢1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methyl-butyryloxy)-naphthalen-1-yl!-heptanoic acid .delta.-lactone of formula (I) and .beta.,.delta.-dihydroxy-7-¢1, 2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methylbuty...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VARGA, ILONA, NAGY, KAROLY, CSEKE, LASZLO, ERDEI, JANOS, SANTHA, GYOERGY, KISS, LAJOS, KASZAS, MIHALY, KISS, ANDRAS, ILKOY, EVA, MORAVCSIK, IMRE, ANDOR, ATTILA, SZABO, ISTVAN M, HALASZ, EDIT, SZABO, ISTVAN, POLYA, KALMAN, MAGYI, ISTVAN, JEKKEL, ANTONIA, AMBRUS, GABOR
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The invention refers to a new a microbial process for preparing .beta.,.delta.-d ihydroxy-7-¢1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methyl-butyryloxy)-naphthalen-1-yl!-heptanoic acid .delta.-lactone of formula (I) and .beta.,.delta.-dihydroxy-7-¢1, 2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methylbutyryloxy)-naphtalen-1-yl!-heptanoic acid of formula (I I), (I) (II) by the aerobic fermentation of the submerged culture of an imperfect fungus stra in biosynthesizing the above compounds, in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product of f ormula (I), which comprises cultivating a strain of the new Aspergillus obsecurus fungu s species producing the above compound(s) of formulas (I) and/or (II), in a temper ature range of 25 to 30.degree.C and, if desired, separating the product(s) formed fro m the fermentation broth, then isolating it in the lactone form of formula (I) and, if desired, purifying the same.