PROCESS FOR THE PURIFICATION OF CYCLOSPORIN

A process is disclosed for the solution chromatographic purification of cyclosporin A from a starling mixture containing one or more of cyclosporin A, B, C, other cyclosporin components that are more polar or more apolar than cyclosporin A, and other like contaminants, by heating the starting mixtur...

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Hauptverfasser:	NAGY, EDIT, RADNAI, FERENC, MAKO, BARTA, BALINT, JANOS, KARACSONY, ERNOE, SZANYA, TIBOR, MARTON, GYULA, STRBKA, GYOENGYI, KERI, VILMOS, MELCZER, ISTVAN, HAJDUFI, CSABA, HANAK, LASZLO, KELEMEN, JANOS, DENCS, JUDIT, DEAK, GYOERGY, KARCZUB, ANITA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A process is disclosed for the solution chromatographic purification of cyclosporin A from a starling mixture containing one or more of cyclosporin A, B, C, other cyclosporin components that are more polar or more apolar than cyclosporin A, and other like contaminants, by heating the starting mixture or an evaporation residue thereof to a temperature from about 80.degree.C to about 115.degree.C, melting the heated starting mixture, and carrying out solution chromatography of the melted material, suitably first in a 48 : 50 : 2 mixture of chloroform, methylene chloride, and ethanol, and then in a mixture of like proportions, of the solvents chloroform, ethyl acetate, and ethanol.